安德莉亚是一个15岁的女孩，与母亲和弟弟住在加的斯。尽管她还是个十几岁的孩子，却过着非常忙碌的生活，平日里她要去高中接弟弟托马斯和菲德尔，还要在家里帮助她工作的母亲。安德莉亚几乎没有时间见她的朋友或做任何其他事情。她决心一定要找回自己生活中缺失的那些东西。

　　伊丽莎白是一位天才外科医生，也是医院里唯一的女性顾问。但在为一位年轻女性做手术时，事情发生了可怕的变化。在一项公开报告外科医生表现的新计划中，她的同事们开始团结起来，伊丽莎白的生活陷入混乱。伊丽莎白坚强而粗鲁，在这个要求最高的领域生存下来并取得了成功。但她能承受一次失误吗？

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　　Queen Latifah主演，设定类似电影和老的剧版，只是从邻家叔叔变邻家大姐，讲述一个有神秘过去、身手不凡的人物大隐隐于市，帮助无辜而无助的平民们，而CIA等也会重新在她的人生中出现。《灵书妙探》夫妻搭档Andrew Marlowe和Terri Miller任该剧运作人和编剧，克里斯·诺斯等

故事来源于真实案例，杜克学生Miriam Weeks为学费变身色情女星Belle Knox